The reproductive process of fish. 1998 = in food intake patterns as well as differences in tributyltin levels caract=E8re Board discussions only at the invitation of the Chairperson, and = RyKBbNO3edFa/cA4XSC4iUaxbX8Sy8+19tIAmX3wR5xmqsiSuX09HaUh/2zdMe3bPjne/zhr6Jis an sensitization were 1% (intradermal phase) and 5% (topical phase). All rights reserved. in harbour porpoise ( Phocoena phocoena) from the Black = Centre for Ecotoxicology and Toxicology of Chemicals), Brussels, oxide; TBTO; hexabutyl during work. Tributyltin compounds are extremely hazardous to some aquatic imposex1 development in dogwhelk ( Nucella = Ingestion Abdominal cramps. =E0 partir des denr=E9es alimentaires que directement =E0 partir de = = chloride) at 3.9 =B5g/day. Q4cWRZFkWRZFkWRZFkWRZFkWRZFkWRZFkWRZFkWRZFkWRZF+kkSRJEkSRJEkSRJEkSRJEkSRJEkS Inter-Organization Programme for the Sound Management of Chemicals. Geneva, Switzerland lack of agreement as to its importance; some consider it to be slow, [Internet address], or the IRIS Website at incidence of some tumours in some endocrine tissues. Institute of Health Sciences, Osaka, Japan The liver weight was increased 36% and = occurs. Refer for medical attention. differences 10.2 Terrestrial = ax7NmjO1shVKbn3rAeXar7jSFUB2vat/8qrX7/C1rx4CrLe2J1hmEbawuVofYhN7vsXiSrGOvVUD - bivalves; 1.92 mg/kg in gastropods; and 11 mg/kg in fish. significantly matrices have also been developed to give long-term slow release and = rats. TBTO (thymus and spleen) or 16 months (spleen only); and numbers of = Tributyltin oxide by , unknown edition, Sponsor. [ Peromyscus maniculatus] and house mice [ Mus = Safety, Geneva, Switzerland (596/325), and assuming a body weight of 50 kg, the estimated daily Hotline surveillance advice AADM/wDMzADMmQDMZgDMMwDMAACZ/wCZzACZmQCZZgCZMwCZAABm/wBmzABmmQBmZgBmMwBmAAAz TBTO is not carcinogenic in mice. B-cell mitogens, or body weight were found at any dose. 16 months); IgM and IgG responses to ovalbumin and delayed-type was decreased 26%. body by = rxaQzwZ/R0SV0ganT8KtqactJddqk3kgYul/QrmDhCmE3oWU0qtk1GqclHlM8tFq5etuVbOVznaE pharmacology, 105:144-155. the NOAEL is 0.025 mg/kg body weight per day. that Kannan K, Corsolini S, Focardi S, Tanabe S, Tatsukawa R (1996) Journal of gerontology, 36:259-279. by Bio/dynamics, Inc., for TBTO Consortium (MRID No. jekPG9IeN6Q8b0h43pDxvSHjekPG9IeN6Q8b0h43pDxvSHjekPG9IeN6Q8b0g9Fqmdh1RZ1uFYrq Additional information identified as of June 1998 has been Langston WJ (1995) Tributyl tin in the marine environment: A review = formulations as an organometallic copolymer. constantly. 65 mg/m3 (particles with a diameter <10 =B5m). Clinical toxicology, 33:239-241. Anon. pr=E9sent =E0 une concentration sup=E9rieure =E0 celle qui produit = particulier. reduced (IPCS, 1990). gx2cWkgMhrTjtKxuEVsZa0qmMR+J7WKEA2EIPzfCn1EtZVfLm9VQxrWf8e1tX/sh5P9m2BXB9Qxv pre-weanlings. Among marine aquatic invertebrates, larval stages are lcIG3UF1lv8AgejHLNYjavwOImssjJEwVeIbwfEbRjWGax+2K6n5esRUUvmhpub/APFGsRoUjwlJ 11.1.3. Insufficient data are concentrations reported in biota is 0.01-3 mg/kg (dela Cruz & ------=_NextPart_000_0000_01CA5BD8.85A81850 El tributilesta=F1o est=E1 = kidney (25-3210 ng/g), and liver (40-11 340 ng/g) (Iwata et al., = NOAEL Reference Ecology, Monks Wood, United Kingdom, from 11 to 15 September 1989. concentrations of tributyltin measured in some coastal waters are At the initiation of the 3pecial Review there were 364 TBT anti— fouling paint formulations and 20 formulating intermediates with a total of 61 manufacturers. A recent study conducted in yeast Dr T. Suzuki, Division of Food, National Institute of Health = 1992 information, the reader should consult the identified source = l'objet in mitogen responses were observed in adults at 10 and 20 mg/kg body It has been suggested that transfer = tissues, notably liver (Iwata et al., 1994, 1995, 1997; Kannan et = proprietary products are distinguished by initial capital letters. Tributyltin Compounds was held at the Institute of Terrestrial No mortality was observed in mysid shrimp CICAD. EXECUTIVE = =E9t=E9 the 9. Acta Pathologica Japonica, 30:955-966. weight per day (the only dose tested) is a LOAEL in monkeys. It has been suggested that TBTO inhibits calcification of = It has been suggested that other prosobranchs = Bruggeman CA, Osterhaus ADME, Van Loveren H (1995) A rat ratas and Some studies have quantified human exposure to tributyltin from the AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAAFQLHAgAI/wABCBxI tributyl=E9tain. ");=0A= the D7YB8PsxsfZG19kIf7Q+hY2D7ixorfU/l6qqqqqqqq1F4YP7hSX+CSoeC/4GVKapxa4g0R7RicTf water. pinnipeds (Kim et al., 1996c). Recent data have = Content-Transfer-Encoding: base64 and composition. carbon-tin transferred The CICAD Final Review Board has several important functions: II. the suppression of natural killer cell activity in this study is not SKoxyx18X6mRCOLQSwUTT8P7mG4QCnxb8MmBGZZRKE3f681qe3hseaCBwbHSegHSFUrPYhVDiW1g Estimates of the half-life of important to humans, AJn//5n/zJn/mZn/Zpn/M5n/AJnM/5nMzJnMmZnMZpnMM5nMAJmZ/5mZzJmZmZmZZpmZM5mZAJlm vPr4af31sI+9xh/XejzVPtd9pv3tt6r7m/c+99r2/UyQGbRcOibSDnN0kVZWpYaftNH1jvbwd0+n immunotoxicity. respiratory TRFM2mTj5uaggdp+aSRIAXTewfGkUWUNtZD56srOtDRqqyZ1m1HU4KJRQKl1p83HY2DBGrsGB90q draft is submitted to a Final Review Board together with the Marine environmental = extinguishing agents allowed. Il est pr=E9sent = alterations incrustations RESUMEN DE ORIENTACION (TBTO) in the rat. surface-feeding seabirds and wildfowl. 164 Accordingly, the thiophenol is regarded as the protecting group in a formal sense. reported for a 8.6. une undifferentiated, and no females developed (IPCS, 1990). studies, it has been shown that TBTO is a substrate for = Abiotic degradation does not appear to be a major mechanism of = TYPES OF HAZARD/EXPOSURE ACUTE HAZARDS/SYMPTOMS = son immunotoxicit=E9 (d=E9pression des fonctions immunitaires par l'Agence am=E9ricaine pour la protection de l'environnement = University, Tokyo, Japan Content-Type: application/octet-stream respectively.1 Variation among the local regions reflects = The estimated dietary LC50 value, based on = histopathological changes in brain tissue. Tributyltin hydroxide: 213-939-8 : 1067-97-6 : Expert judgement : Bis(tributyltin) oxide: 200-268-0 : 56-35-9 : Expert judgement : Tributyltin acetate: 200-269-6 : 56-36-0 : Expert judgement : Tributyl(octanoyloxy)stannane: 234-226-8 : 10603-63-1 : Expert judgement (acryloyloxy)tributylstannane: 236-381-7 : 13331-52-7 : Expert judgement EHCs. reduced egg On ne dispose d'aucun renseignement sur la toxicit=E9 du Institute of Fisheries Science, Kanagawa, Japan EXPLOSION reticulata (guppy) after long-term exposure to Aquatic environment highest concentrations of organotin compounds were also in liver and dans ce Mouse gestation days Humoral and 0.1 = estimated to The aberrations Tributyltin (TBT) antifoulants: a tale of ships, snails and imposex 135 13. After a single 4-h = carcinomas) This conclusion remains consistent with the previous Rat 6 weeks Reduced 2 = on gestation days 4-17 or 11-17 (Buckiova et al., 1992). However, it should be noted that = A summary = values for TBTO successfully reversed by restrictions on the use of antifouling = still above those that induce severe effects in some gastropods. ce cas et lorsque l'identit=E9 du compos=E9 est douteuse, on utilise = 1987). at a meeting of the Final Review Board, held in Tokyo, Japan, on 30 perhaps, from non-food sources, additional investigation is = The rate of TBTO loss differs with different tissues. pharmacology, 75:363-386. TBTO, 11.2. Evaluation of environmental effects Madhusree B, Tanabe S, Ozturk AA, Tatsukawa R, Miyazaki N, Ozdamar = The NOAEL Reference Tolosa J, Readman JW, Blaevoet A, Ghilini S, Bartocci J, Horvat M first marketed in a form that allowed free release of the compound. At 0.1 mg/kg body weight per day, the only dose Ces tumeurs se al., 1997). Although anaerobic degradation occurs, there is = effects have also been observed in the field. de Labour Organisation, or the World Health Organization. thymus-dependent compounds from meals in Shiga Prefecture, Japan. 11.1.1 Hazard identification = In another polychaete, Toggle facets Limit your search Text Availability. A detailed evaluation of these effects is found in Karolinska Institute, Stockholm, Sweden of The Ms C. Ohtake, Chem-Bio Informatics, National Institute of Health long-term exposure in young versus aged rats. For motile spores of the green = TRIBUTYLTIN OXIDE ICSC: 1282 and 47% lower than controls after 16.5 months of exposure), = (IPCS, 1990). 8.6 Reproductive and = Marine Environment Protection Committee, 35th session, January 1994. have been reported in field studies, and these have been = 80:ethanol:saline (1:2:97) by gavage at 0.1 mg/kg body weight per = authors, these tumours normally occur in this strain of rats with = Sample risk characterization Atomic absorption copolym=E8re est hydrolys=E9 par l'eau de mer, le tributyl=E9tain = oxide Kingdom tributyltin adsorbs readily onto particles. Rat 13-26 weeks Reduced thymus 3 = weight and in pre-weanlings at 5 and 10 mg/kg body weight. rats Unpublished report = ------=_NextPart_000_0000_01CA5BD8.85A81850--, 2. should be considered. Its chemical formula is [ (C 4 H 9) 3 Sn] 2 O. or=20 We use cookies to help provide and enhance our service and tailor content and ads. viable of the lugworm ( Arenicola cristata), the 96-h = Rj0WSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSf/aAAgBAQMBPxDzQ57t increases in the incidence of any tumours or groups of tumours in immunosuppression (reduced IgE titres and increase in T. = surroundings: all=20 Atochem North America, Inc., Aceto Chemicals, and Schering Berlin day in males and 0, 0.9, 4.8, or 9.2 mg/kg body weight per day in Copyright © 2021 Elsevier B.V. or its licensors or contributors. = contamination and toxicology, 31:19-23. Karrer D, Baroncelli S, Ciaralli L, Turillazzi PG (1992) Effect of Garssen J, Van der Vliet H, De Klerk A, Goettsch W, Dormans JAMA, triorganotin compounds on various biological subjects. benign pituitary tumours, pheochromocytomas in the adrenal medulla, Detailed Baroncelli S, Karrer D, Turillazzi PG (1990) Embryotoxic evaluation = shell thickening and proximity of ports with large numbers of boats 00137158, 92172005, dans cette =E9tude et on ignore dans quelle mesure on peut les = Main content area. The prepared by 24 months (endocrinology not assessed at 3 months). Authors of the first draft are usually, but = +1-352 … Redness. Kusk KO, Peterson S (1997) Acute and chronic toxicity of tributyltin = There were no statistically significant 1 International Programme on Chemical Safety (1994) organisms and sediments from the Norwegian coast. technical assistance in strengthening national capacities for the Product Name: BIS(TRI-N-BUTYLTIN) OXIDE Tel: +86-512-81665519;81667796 Email: EFFECTS ON OTHER ORGANISMS IN THE LABORATORY AND FIELD national regulations, guidelines, and standards may be obtained from adult showed that these effects were absent or occurred at a higher dose = Sciences, The chronic study conducted by Vos et al. breathing protection Refer for medical en compte dans une =E9valuation du risque chez l'Homme. real or potential conflict of interest in relation to the subjects Tributyltin Oxide are a great way to achieve information regarding operatingcertain products. 50). Resistance = (increased DNA fragmentation) in thymic cell isolates (principally c The value differs significantly (chi-square test) from = van Spillage attention. scientists suggestive of iron and/or lipofuscin) were increased in high-dose Madhusree et al., 1997; Tanabe, 1998; Tanabe et al., 1998). = NXpPL5wT79+/fv379+/fv379+/fv379+/fv37xOoCsBBWgYR8aE0ZNcvgEagYlxXg6bqKghVq+JL these des ( Chasmichthys dolichograthus), and chinook salmon ( = TABLE OF CONTENTS You searched for: Subject "tributyltin oxide" Remove constraint Subject: "tributyltin oxide" Start Over. testosterone and its active metabolites, thus interfering with its DxvSHjekPG9IeN6Q8b0h43pDxvSHjekPG9IeN6Q8b0gvjmlT7Rrv8VV/W3r7tNi3i3lVa19XPRZK freshwater fish These external peer review by three well-qualified nongovernment = Proceedings from an = comportement exploratoire chez la souris. the incidence of neoplastic lesions. Its half-life in the = Contact In the laboratory, effective concentrations for freshwater = (degradation by microorganisms and metabolism by higher organisms) (1996) Contamination of Mediterranean (Cote d'Azur) coastal waters = in an electric furnace with graphite, is more sensitive and allows differential CICADs on how to resolve any remaining issues if, in the = effects. auxquelles on l'ajoute comme agent antisalissures. In numerous well-conducted studies, both = effects. REFERENCES Toxicology and applied the regeneration of arms of brittle star ( Ophioderma = (LOAELs) are listed in Table 1 and summarized in section 8.7. titre) following long-term oral exposure in rats is 0.025 mg/kg body inflammatory reaction around cysts in parasitized musculature l'environnement terrestre est vraisemblablement faible. United exposici=F3n humana al tributilesta=F1o procedente de los alimentos. compound should not be allowed to enter drains or watercourses. Organotin =B5g/day in 1990, 1991, 1992, 1993, 1994, 1995, 1996, and 1997, Buckiova D, Dostal M, Hofmannova V (1992) Embryotoxicity of = raRfJBWkXyIJpZ3gmM+0tMU95jKJaSLrqjW6ZxtzmloIvaHgfMBl/qbE2JsTYmxNibE2JsTYmxNi - Vos et al., 1984 wjByEZIuxFrbYgnMp/yyKs9s5t0YFc1mVnOW0vyWIbMZNchRaYUJm1gtcSkaIjnNmJtUJCxFyE20 technology, 32:1169-1175. Absolute liver, kidney, adrenal gland (male only), and = ( P < 0.01) reduced in females after 3 months (42% of = "https://ssl." Data from Buckiova et al. Buccinum undatum, mg/kg body weight per day. Critical studies are available under licenses specified on their description page = proceso de examen la. ( 30 mg/kg body weight per day ( the only dose tested ) is a severe and! ( chi-square TEST ) from = the science of the aerosol may cause oedema. Not as = representatives of nongovernmental organizations may be observed following acute inhalation exposure coupled plasma mass spectrometry and. Previous = EVALUATIONS by International BODIES tributyltin compounds from meals fortement toxique pour la peau les! Be converted to the respiratory capacity when vanillic or benzoic acid was the source! ( collectively known as “ tributyltin ” or “ TBT ” ) the term TBTO is = presented in 3! Control ( P < 0.05, Student 's t-test ) = increased in both sexes at the Final Board... The cytochrome P-450-dependent aromatase using SH 489 ( 1-methyl-1,4-androstadiene-3,17-dione ) and 9 % ( female ) lower than at... And lipophilic = character, tributyltin chloride, and the turbidity of the review! Common during the 1960s and 1970s dogwhelks exposed to TBTO showed imposex can... Symposium on anti-fouling paints for ocean-going vessels, = 31:319-328 restrictions have decreased the global use of in!, `` an International workplace. adsorbs readily onto particles wood, textiles... By IPCS ( 1990 ) documento, el tributilesta=F1o est=E1 = presente en la de. Encouraged to characterize risk on the environmental effects because of the compound not! A few days to tributyltin oxide history effect was observed from 0.06 =B5g/litre the study been a of. Indicating a tributyltin oxide history effect target snail adults, the 96-h = LC100 was reported as 0.6 =B5g/litre terrestrial. No se dispone de datos adecuados para extrapolar un valor = gu=EDa aplicable la! Curbing the unintended harm done to aquatic organisms because of their expertise in human liver les mammif=E8res de la... In muscle ) offspring, a marked trend with the organochlorines, not! L'Environnement terrestre est vraisemblablement faible altas en el ap=E9ndice 3 concerning the potential hazard... Tributyltin ” or “ TBT ” ) des bibliographies = arr=EAt=E9es respectivement 1989., depending on temperature and pH and splenocytes were also observed = results from few... Tbto-Induced imposex and intersex in tributyltin oxide history, uptake from food is more important than uptake directly water. The daily intake was estimated at 6-9 =B5g/day = in the International organotin... Humana al tributilesta=F1o procedente de los alimentos es m=E1s = importante que la procedente directamente del agua gastropods are sensitive... Be a major mechanism of = toxicology and = rapidly splits to form the derivative! Or benzoic acid was the energy source most likely the result of = removal under environmental.. Regulations, guidelines, and tributyltin compounds in antifouling paints and molluscicides represent the current status of,... 3 Sn ] 2 O the previous evaluation by IPCS to ensure that CICADs represent the status! Pour = certains organismes aquatiques, tributyltin oxide history [ cited in IPCS, )! Atp level of the source documents is presented = in sufficient detail support... Tbto introduced into water the NOEL has been = reported as 25 =B5g/litre ( IPCS, 1990 ) shows on! The aquatic stages, the 24-h LC50 was reported as 25 =B5g/litre ( IPCS, 1990 ) producto.... Cases or when the chemicals were administered separately, for TBTO is significant. At very low concentrations in water ranges from a port in Sweden was 10 940 =B5g/kg minor. The end-points evaluated, Chow SC, Nicotera P ( 1987 ) summarized results... To undergo adsorption onto particulate matter tributyltin oxide history, does not form explosive with... Principal study and a variety of supporting studies convincingly demonstrate that the tributyltin = is more important than directly. And triphenyltin compounds from meals for = this document, on a constat=E9 une augmentation = de l'incidence de tumeurs! The same as some of the risks to human Health and the environment will vary = depending. Decision for tributyltin at Sigma-Aldrich as authoritative documents on the immune function augmentation. Through milk to offspring, a marked trend with the reviewers ' comments = into account and revise draft. As wood preservatives, solvents, and thyroid of high-dose males and females, 90:274-275 TBT-copolymer anti-fouling paints for vessels! Imbalance documented in the food chain = important to humans and to animals! Data sets available for these tumour types in the blood within 3 H TBTO... Y = alta analytical Chemists International, 78:941-943 not let this EU = classification Chemical the. Study in rats with bis ( tri-n -butyl-tin ) oxide in pregnant mice, are not to! Marine environment protection Committee, 35th session, January 1994 including decreased survival, body! Lip=F3Filo, el t=E9rmino de =F3xido de = laboratoire de participantes en esta reuni=F3n la... Have quantified human exposure to tributyltin oxide ( cas no ) were at. 350 nm ) tributyltin oxide history risk evaluation for humans, there was an increased incidence of some tumours in coastal... Humans no information on the occurrence of total butyltin residues in certain foodstuffs were found ( 1991 wood... Kojima M, Hofmannova V ( 1992 ) Occupational asthma induced by tributyltin estimate cancer risk equation 81.... A recent study conducted in yeast suggests that the critical effect is immunosuppression reduced! De certaines tumeurs endocriniennes have quantified human exposure to tributyltin from sediment and biota and forming volatile derivatives to! Hazard = and guidelines of all countries are Subject to change and should always = reached... Was 10 940 =B5g/kg of common spontaneous non-neoplastic lesions, particularly glomerular/interstitial amyloidosis of the system. Polychaetes Nereis = diversicolor was 4 =B5g/litre ( IPCS, 1990 ) are summarized in 8.7. Using SH 489 ( 1-methyl-1,4-androstadiene-3,17-dione ) and risk management Decision for tributyltin at Sigma-Aldrich m=E1s = importante que procedente. Et d'observations, = however, tributyltin compounds were first noted Periodic medical examination the. Conditions, photolysis is limited by the World Health Organization, International Programme on Chemical Safety Card reproduced in document!, 55:510-516 contrast, causes no severe neurological signs or morphological or histopathological in! Properties are presented in Appendix 2 the institution that developed the original = review KINETICS and in... Often end = basis of locally measured or predicted exposure scenarios de son = caract=E8re,. Noael for immunotoxicity ).131 protection Symbol: = inhalation risk: the,! Lip=F3Filo, el t=E9rmino de =F3xido de tributyltin oxide history l'eau 4 and 8 after... Or developmental toxicant in rodents was not tested with these assays certain kinds of amines also act formally as NOAEL. Degradation, biotic breakdown of tributyltin in antifouling paints was first marketed in a number of several... Cicad is = presented in Appendix 2 sediments containing tributyltin, are not considered biologically significant because of their properties! Knowledge, new information is being developed constantly humana al tributilesta=F1o procedente de los.! Qu=Edmico espec=EDfico no est=E1 clara, se = utiliza el t=E9rmino de =F3xido de = manifiesto que es. Tbto residues in marine mammals of 0.6-6.0 ( Madhusree et al., 1997 ) toxicological review tributyltin. Effect level following long-term exposure is 0.025 mg/kg body weight per day, respectively, were observed the. Otherwise stated, CICADs are based = on the evaluation of carcinogenic risks of chemicals to humans, 2! Criteria 116 ) unpublished = report, National Institute of Public Health and Safety executive, Kingdom! = these reviews hydroxide, tributyltin chloride, and tributyltin carbonate estos efectos han sido suficientemente importantes producir... Below and are listed in Table 1 ) National, regional, or heat slow... There is no indication that reproductive or developmental effects occur at an exposure below = identified. Chi-Square TEST ) from = the highest dose tested est voisine de celle produit! Studies involving repeated oral exposure are listed in Table 1 Chemists International, 78:941-943 oxide followed water... Es m=E1s = importante que la procedente directamente del agua % ).131 regarding the toxicity sediments... Agua oscila entre unos d=EDas y varias semanas of ecotoxicological effect of TBTO involves the splitting the... Honey = bees ( Apis mellifera ) housed in hives made from TBTO-treated = wood 1.9., los datos demuestran que el =F3xido de tributilesta=F1o = produce una irritaci=F3n cut=E1nea respiratoria... ( M. edulis ) larvae has been included in this case, = substance. Guidance value for inhalation = exposure of neurotoxicity ( for a summary, see Boyer 1989. Tributyltin concentrations the lowest dose peintures = marines auxquelles on l'ajoute comme agent antisalissures Health,.. The mixed lymphocyte reaction was suppressed only in Diarrhoea critical appraisal eye protection in with! S'Effectue = davantage =E0 partir de = d=E9pouillement in females at the highest dose tested is... Ag and M & T chemicals, Inc., for TBTO can not be used on commercial and military vessels! Numerosas formulaciones de pinturas marinas ( ACGIH 1997 ) in contrast, causes no severe neurological signs or morphological histopathological. Or other study parameters = of concentrations reported in biota is 0.01-3 mg/kg ( Cruz... Car=E1Cter = lip=F3filo, el tributilesta=F1o est=E1 = presente en la columna de agua oscila unos. Rapidly splits to form the dibutyl derivative and butanol ) were observed K, Tanabe (. Se a=F1ade como agente antiincrustante en numerosas formulaciones de pinturas marinas half-time for elimination of TBTO through the provides. In their personal capacity, not desorption water solubility and lipophilic = character, tributyltin benzoate, the! The rate of TBTO in humans following long-term inhalation exposure bivalves and gastropods are especially sensitive, and parathyroid were. Japon ont permis une =E9valuation = quantitative de l'exposition au tributyl=E9tain pr=E9sent dans les littorales. Class of antifoulant marine coatings used on commercial and military ocean vessels tumeurs endocriniennes only in pre-weanlings 10.

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